Structural units of human 7S gamma globulin.
نویسنده
چکیده
منابع مشابه
Antigenic Relationships between Immune Globulins and Certain Related Paraproteins in Man
The antigenic properties of normal 19S gamma-globulin, pathologic macroglobulins, beta(2A)-myeloma proteins, and Bence Jones proteins have been compared with 7S gamma-globulin and the small 3.5S units derived from it by gel diffusion precipitin techniques. These studies demonstrate that the determinant groups on the 7S gamma-globulin molecule responsible for the cross-reaction with each of the ...
متن کاملStudies on Structural Units of the Γ-globulins
When human and rabbit 7S gamma-globulins were reduced in strong urea solutions by a number of procedures, their molecular weights fell to approximately (1/3) of the original values. Partial separation of the reduction products was achieved using chromatography and starch gel electrophoresis in urea solutions. One of the components of reduced human 7S gamma-globulin was isolated by chromatograph...
متن کاملTwo Major Types of Normal 7s Γ-globulin
Normal 7S human gamma-globulin was found to contain two fundamental antigenic groups of molecules. The group 1 molecules of normal gammaglobulin correspond antigenically to group 1 multiple myeloma proteins and Bence Jones proteins; and group 2 molecules of normal gamma-globulin correspond antigenically to group 2 multiple myeloma proteins and Bence-Jones proteins. Among pooled human Fr II and ...
متن کاملAntigenic Relationships of Bence Jones Proteins, Myeloma Globulins, and Normal Human Γ-globulin
By means of immunodiffusion and immunoelectrophoresis study has been made of antigenic relationships of Bence Jones proteins, and the three classes of normal and pathological immunoglobulins, 7S gamma, beta(2A), and beta(2M). All thirty-nine Bence Jones proteins studied could be classified into either one of two distinct antigenic types, A or B. Both types are related to the immunoelectrophoret...
متن کاملThe Immunoglobulins of Mice
Two classes of 7S gamma-globulins are identified in normal mouse serum and are designated 7S gamma(2)-globulins and 7S gamma(1)-globulins. These two immunoglobulin classes are similar in size. They differ in range of electrophoretic mobility, in specific antigenic determinants, and in genetically determined isoantigens. Four classes of immunoglobulins in mouse serum, i.e. 7S gamma(2)-, 7S gamma...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 39 شماره
صفحات -
تاریخ انتشار 1960